Flight, Laura, Dr

Dr Laura Flight

MMath, MSc, PhD

School of Medicine and Population Health

Honorary �鶹��Ƶ Fellow

Scientific Adviser, National Institute for Health and Care Excellence

l.flight@sheffield.ac.uk

Full contact details

Dr Laura Flight
School of Medicine and Population Health

Profile

I am currently a Scientific Adviser in the Science Policy and �鶹��Ƶ Team at the National Institute for Health and Care Excellence (NICE).

Previously I worked in SCHARR as a �鶹��Ƶ Fellow in Health Economics and Statistics. I still maintain an interest in methodological research focussing on innovative approaches to the design and conduct of clinical trials with an emphasis on how novel statistical methods can be applied in practice.

My PhD research explored the use of health economics in the design and analysis of adaptive clinical trials.

Qualifications: MMath (Sheffield), MSc (Sheffield), PhD (Sheffield)

�鶹��Ƶ interests

Methods for undertaking health economic evaluations alongside clinical trials.
Value of information analysis.
The use of health economics in the design, monitoring and analysis of adaptive clinical trials.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Wason JMS, Dimairo M, Biggs K, Bowden S, Brown J, Flight L, Hall J, Jaki T, Lowe R, Pallmann P , Pilling MA et al (2022) . BMC Medicine, 20(1).
Flight L, Julious S, Brennan A & Todd S (2021) . Medical Decision Making.
Wilson N, Biggs K, Bowden S, Brown J, Dimairo M, Flight L, Hall J, Hockaday A, Jaki T, Lowe R , Murphy C et al (2021) . BMC Medicine, 19(1).
Qian Y, Walters SJ, Jacques R & Flight L (2021) . BMJ Open, 11(9).
Hykin P, Prevost AT, Sivaprasad S, Vasconcelos JC, Murphy C, Kelly J, Ramu J, Alshreef A, Flight L, Pennington R , Hounsome B et al (2021) . Health Technology Assessment, 25(83).
Pennington R, Alshreef A, Flight L, Metry A, Poku E, Hykin P, Sivaprasad S, Prevost AT, Vasconcelos JC, Murphy C , Kelly J et al (2021) . PharmacoEconomics.
Pennington BM, Hernández-Alava M, Hykin P, Sivaprasad S, Flight L, Alshreef A & Brazier J (2020) . Value in Health.
Flight L, Julious S, Brennan A, Todd S & Hind D (2020) . Trials, 21(1).
Flight L, Arshad F, Barnsley R, Patel K, Julious S, Brennan A & Todd S (2019) . Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes �鶹��Ƶ, 22(4), 391-398.
Candlish J, Teare MD, Dimairo M, Flight L, Mandefield L & Walters SJ (2018) . BMC Medical �鶹��Ƶ Methodology, 18(1), 105-105.
Pallmann P, Bedding AW, Choodari-Oskooei B, Dimairo M, Flight L, Hampson LV, Holmes J, Mander AP, Odondi L, Sydes MR , Villar SS et al (2018) . BMC Medicine, 16.
Flight L, Allison A, Dimairo M, Lee E, Mandefield L & Walters SJ (2016) . BMC Medical �鶹��Ƶ Methodology, 16.
Flight L, Julious SA & Goodacre S (2016) . Emergency Medicine Journal, 34, 243-248.
Hatfield I, Allison A, Flight L, Julious SA & Dimairo M (2016) . Trials, 17(1).

Reports

Forster M, Flight L, Corbacho B, Keding A, Ronaldson S, Tharmanathan P, Welch C, Brennan A & Chick S (2021) Report for the EcoNomics of Adaptive Clinical Trials (ENACT) project: Application of a Bayesian Value-Based Sequential Model of a Clinical Trial to the CACTUS and HERO Case Studies (with Guidance Material for Clinical Trials Units)

Preprints

Flight L, Brennan A, Chick SE, Forster M, Julious S & Tharmanathan P () Value-Adaptive Clinical Trial Designs for Efficient Delivery of �鶹��Ƶ – Actions, Opportunities and Challenges for Publicly Funded Trials.

All publications

Journal articles

Wason JMS, Dimairo M, Biggs K, Bowden S, Brown J, Flight L, Hall J, Jaki T, Lowe R, Pallmann P , Pilling MA et al (2022) . BMC Medicine, 20(1).
Flight L & Julious SA (2022) . Pharm Stat.
Flight L, Julious S, Brennan A & Todd S (2021) . Medical Decision Making.
Wilson N, Biggs K, Bowden S, Brown J, Dimairo M, Flight L, Hall J, Hockaday A, Jaki T, Lowe R , Murphy C et al (2021) . BMC Medicine, 19(1).
Qian Y, Walters SJ, Jacques R & Flight L (2021) . BMJ Open, 11(9).
Hykin P, Prevost AT, Sivaprasad S, Vasconcelos JC, Murphy C, Kelly J, Ramu J, Alshreef A, Flight L, Pennington R , Hounsome B et al (2021) . Health Technology Assessment, 25(83).
Pennington R, Alshreef A, Flight L, Metry A, Poku E, Hykin P, Sivaprasad S, Prevost AT, Vasconcelos JC, Murphy C , Kelly J et al (2021) . PharmacoEconomics.
Pennington BM, Hernández-Alava M, Hykin P, Sivaprasad S, Flight L, Alshreef A & Brazier J (2020) . Value in Health.
Flight L, Julious S, Brennan A, Todd S & Hind D (2020) . Trials, 21(1).
Flight L, Arshad F, Barnsley R, Patel K, Julious S, Brennan A & Todd S (2019) . Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes �鶹��Ƶ, 22(4), 391-398.
Candlish J, Teare MD, Dimairo M, Flight L, Mandefield L & Walters SJ (2018) . BMC Medical �鶹��Ƶ Methodology, 18(1), 105-105.
Pallmann P, Bedding AW, Choodari-Oskooei B, Dimairo M, Flight L, Hampson LV, Holmes J, Mander AP, Odondi L, Sydes MR , Villar SS et al (2018) . BMC Medicine, 16.
Flight L & Julious SA (2016) . Pharmaceutical Statistics.
Flight L, Allison A, Dimairo M, Lee E, Mandefield L & Walters SJ (2016) . BMC Medical �鶹��Ƶ Methodology, 16.
Flight L, Julious SA & Goodacre S (2016) . Emergency Medicine Journal, 34, 243-248.
Hatfield I, Allison A, Flight L, Julious SA & Dimairo M (2016) . Trials, 17(1).
Flight L & Julious SA (2016) . Pharmaceutical Statistics, 15(1), 80-89.
Flight L & Julious SA (2016) . Pharmaceutical Statistics, 15(1), 68-74.
Flight L & Julious SA (2016) . Pharmaceutical Statistics, 15(1), 75-79.
Flight L & Julious SA (2015) . Pharmaceutical Statistics, 14(1), 74-78.
Pennington B, Alshreef A, Flight L, Metry A, Poku E, Hykin P, Sivaprasad S, Prevost AT, Vasconcelos JC, Murphy C , Kelly J et al () . PharmacoEconomics.

Conference proceedings papers

Flight L, Julious S, Brennan A & Todd S (2020) . 41st Annual Meeting of the Society for Medical Decision Making Portland, Oregon, October 20–23, 2019, Vol. 40(1) (pp E1-E379)
Pennington B, Alshreef A, Flight L, Hykin P, Sivaprasad S, Brazier JE & Hernández M (2019) . Value in Health, Vol. 22(Suppl. 3) (pp S891-S891). Copenhagen, Denmark, 2 November 2019 - 6 November 2019.
Flight L, Alshreef A, Hykin PG, Sivaprasad S, Pennington B, Kelly J, Murphy CL & Brazier JE (2019) . Value in Health, Vol. 22(Suppl 3) (pp S664-S664). Copenhagen, Denmark, 2 November 2019 - 6 November 2019.
Flight L, Baxter S & Khan S (2019) . Trials, Vol. 20(Supplement 1) (pp 25-25). Brighton, UK, 6 October 2019 - 9 October 2019.
Flight L, Hind D, Julious S, Brennan A & Todd S (2019) . Trials, Vol. 20(Supplement 1) (pp 109-109). Brighton, UK, 6 October 2019 - 9 October 2019.

Reports

Forster M, Flight L, Corbacho B, Keding A, Ronaldson S, Tharmanathan P, Welch C, Brennan A & Chick S (2021) Report for the EcoNomics of Adaptive Clinical Trials (ENACT) project: Application of a Bayesian Value-Based Sequential Model of a Clinical Trial to the CACTUS and HERO Case Studies (with Guidance Material for Clinical Trials Units)

Posters

Candlish J, Teare D, Cohen J, Dimairo M, Flight L, Mandefield L & Walters S (2017) Methods to analyse partially nested randomised controlled trials.
Walters S, Lee E, Flight L, Mandefield L, Dimario M & Allison A (2015) Analysis and reporting of individually randomised controlled trials with clustering in one arm only: how should we do it?.

Datasets

Pennington R, Hernandez M, Hykin P, Sivaprasad S, Flight L, Alshreef A & Brazier J .

Preprints

Robertson DS, Choodari-Oskooei B, Dimairo M, Flight L, Pallmann P & Jaki T (2021) Point estimation for adaptive trial designs, arXiv.
Flight L, Brennan A, Chick SE, Forster M, Julious S & Tharmanathan P () Value-Adaptive Clinical Trial Designs for Efficient Delivery of �鶹��Ƶ – Actions, Opportunities and Challenges for Publicly Funded Trials.