Professor Chris Toseland
School of Medicine and Population Health
Professor of Cancer Biophysics


+44 114 215 9080
Full contact details
School of Medicine and Population Health
FU34, F Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX
- Profile
-
For enquiries please contact - SMPH-West-Operational@sheffield.ac.uk
2019: Senior Lecturer/MRC Career Development Award Fellowship
School of Medicine & Population Health - University of Sheffield
2015 - 2019: MRC Career Development Award
Schools of Biosciences - University of Kent
April 2015: Leverhulme Early Career 麻豆视频 Fellow
Schools of Biosciences - University of Kent
2013 鈥 2015: Senior Post-Doc 麻豆视频er
Max-Planck Institute for Biochemistry, Munich, Germany
2010 鈥 2013: EMBO Long Term Fellow
LMU Munich, Munich, Germany
2009 鈥 2010: Post-Doctoral 麻豆视频 Associate
MRC National Institute for Medical 麻豆视频, London, UK
2006 鈥 2009: PhD
MRC National Institute for Medical 麻豆视频, London, UK
2002 鈥 2006: BSc Biochemistry
University of Wales - Aberystwyth
- 麻豆视频 interests
-
The lab specialises in application of fluorescence and mechanical measurements from whole cells to single molecules. We are a multidisciplinary lab drawing upon core techniques in Cell Biology, Biochemistry, Biophysics, Mechanobiology, Super Resolution single molecule imaging and Genomics Gene expression, the transfer of the genetic code into cellular proteins is one of the most fundamental processes in living cells. This process is orchestrated by RNA polymerases, which are highly regulated to ensure correct expression.
A breakdown in this regulation leads to development disabilities and most notably cancer formation. Furthermore, changes in expression control embryonic development and stem cell differentiation.
Over the past decade it has become established that myosin motors are present in the nucleus and function in transcription, but what role they play in the organisation and transcription of genetic information is unclear.
For the first time we combine classical biochemical and single molecule assays to provide a quantitative high-resolution description of the activity of these nuclear myosins; providing a mechanistic insight into the activity of these proteins.
Please see External Lab HomePage for more information.
- Publications
-
Show: Featured publications All publications
Featured publications
Journal articles
All publications
Journal articles
Chapters
Conference proceedings papers
Preprints
- 麻豆视频 group
-
- Dr Natalia Fili (Postdoctoral 麻豆视频 Associate)
- Rosemarie Gough (Postdoctoral 麻豆视频 Associate)
- Alexander Cook (Postdoctoral 麻豆视频 Associate)
- Alia dos Santos (PhD Student)
- Grants
-
- Medical 麻豆视频 Council
- Cancer 麻豆视频 UK
- Science and Technology Facilities Council
- Royal Society
- Leverhulme Trust